Nicorette Gum Efficacy

Proven efficacy of Nicorette Gum

Abstinence rates 2X higher than placebo¹*^†‡

• The use of 4-mg nicotine gum more than tripled quit rates vs. placebo at 30 days among patients with a history of treatment failure
• TTFC is an appropriate measure of dependence among smokers

*Abstinence rates with Nicorette Gum were statistically significantly different from placebo at P_{linear trend}=0.02.

†Highly dependent smokers have their first cigarette within 30 minutes of waking up.

‡A secondary analysis of a large, randomized, placebo-controlled trial that included subjects (N=608) who were ≥20 years of age, smoked ≥5 cigarettes per day, and were in good overall health. Subjects were randomly assigned to placebo or 2-mg or 4-mg nicotine gum and were instructed to quit smoking. Participants had brief (5- to 10-minute) individual smoking-cessation counseling sessions at each study visit, beginning with the quit day. Abstinence status was self-reported and biochemically verified at 9 time points: days 1, 7, 14, and 30; months 2, 3, 6, and 19; and 1 year.