Clinical Study Data: Mobility Improvement

Voltaren is clinically proven to reduce pain-on-movement and improve mobility

Nearly 26 million US adults are unable to perform everyday activities due to arthritis

According to the CDC, nearly 26 million adults in the US are unable to perform everyday activities due to arthritis. Not only can this prevent them from performing day-to-day functions, but being less active can lead to other conditions such as cardiovascular diseases, diabetes, and obesity.¹

Study Objective & Methodology

The purpose of this post-hoc analysis was to evaluate the scores from the individual Australian/Canadian Osteoarthritis Hand Index (AUSCAN) questions from an 8-week randomized, double-blind, placebo-controlled trial of diclofenac sodium 1% gel (DSG) vs vehicle in the treatment of hand OA. AUSCAN questions were scored using a scale of 0 (no pain/stiffness/difficulty)-100 (extreme pain/stiffness/difficulty) at baseline and at weeks 1, 2, 4, 6 and 8 to assess patients’ ability to perform daily activities such as getting dressed, turning doorknobs and faucets, and cooking.

Results

DSG demonstrated efficacy with reduction of pain subscale question scores at week 6 by 42%-44% (33%-35% for vehicle), stiffness scores by 42% (30% for vehicle) and physical function subscale scores by 39%-45% (27%-33% for vehicle).
The DSG scores at week 6 demonstrate a 39-45% improvement from baseline in performing daily activities including turning objects such as doorknobs and faucets, getting dressed, and cooking compared to 27-35% reductions from baseline for vehicle.
Statistically significant differences favoring DSG over vehicle were observed at weeks 4 and 6 (primary endpoints) in all categories.

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