Advil safety and tolerability
![Graphic showing COX 1 and COX 2 selectivity and risk profile](https://i-cf65.ch-static.com/content/dam/cf-consumer-healthcare/health-professionals/en_US/pain-relief/advil/advil_safety_selectivity_chart_970x416.png?auto=format)
Not all NSAIDs are the same: Advil has a balanced selectivity profile targeting COX 1 and COX 2 enzymes3
Greater balance of selectivity reduces risk
The medicine in Advil is one of the most centrally balanced between COX 1 and COX 2 selectivity among NSAIDs,3 supporting its good tolerability by patients.
Pharmacokinetic data
Advil: Rapidly metabolized to minimize systemic exposure2
The medicine in Advil is highly protein bound and rapidly metabolized, minimizing systemic exposure:
- Rapidly absorbed and distributed throughout the body
- Rapid onset of efficacy—less than 30 minutes
- Results in lower blood concentration levels while delivering relief
Advil has 35+ years of clinical studies & real-world evidence confirming its safety profile
COX inhibitors, like NSAIDs, are widely used due to their anti-inflammatory and antipyretic properties and are indicated for mild pain by the WHO.7
![Graphic showing percentages of adverse event rates](https://i-cf65.ch-static.com/content/dam/cf-consumer-healthcare/health-professionals/en_US/pain-relief/advil/advil_safety_accordion_table_970x416.png?auto=format)
Favorable overall safety profile
Results of a meta-analysis of 15 double-blind, randomized, placebo-controlled clinical studies:
No significant differences in AEs among or between ibuprofen, acetaminophen, or placebo-treated patients1,4*
- Clinical studies show no significant differences were observed in overall frequency of AEs between the medicine in Advil and Tylenol, both of which had rates similar to placebo
- AEs with OTC doses of Advil were generally present at similar rates as placebo†
Additionally, unlike prescription doses of ibuprofen, OTC doses of Advil, when taken as directed, have a low risk for occurrence of AEs across all body systems2
*When used as directed.†AE rates increased with higher dosing similar to Rx.
Recommend Advil—proven effective pain relief with a favorable safety profile.
Advil has 35+ years of clinical studies & real-world evidence confirming its safety profile.
View the benefits
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Advil Tablets
Experts and patients have trusted Advil for safe and effective pain relief for 35+ years.
![Advil liqui-gels](https://i-cf65.ch-static.com/content/dam/cf-consumer-healthcare/health-professionals/en_US/pain-relief/advil/advil-ligui-gels-750x421-min.png?auto=format)
Advil Liqui-Gels
Fast-acting formulation to relieve acute patient pain.
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![PATH-BP clinical summary](https://i-cf65.ch-static.com/content/dam/cf-consumer-healthcare/health-professionals/en_US/pain-relief/advil/pathbp_750x421.png?auto=format)
An important clinical study
This double-blind, placebo-controlled, crossover study examined the effects of regular acetaminophen dosing on blood pressure in individuals with hypertension.
![Product samples](https://i-cf65.ch-static.com/content/dam/cf-consumer-healthcare/health-professionals/en_US/pain-relief/advil/samples_750x421.png?auto=format)
Patient samples for your practice
Help patients get clinically proven, safe pain relief with free samples.