Advil Efficacy
Advil® treats pain caused by inflammation at the source
The #1 expert* recommended and patient preferred NSAID, Advil non-selectively inhibits COX-1 and COX-2 enzymes, effectively blocking prostaglandin production and pain signaling.
*Defined as healthcare professionals, excluding pharmacists.
How Advil works
Watch our new MOA video to learn more about the science behind Advil.
Ibuprofen
Ibuprofen, a “traditional” NSAID*, decreases the synthesis of pain- and inflammation-promoting prostaglandins via nonselective inhibition of COX-1 and COX-2.
*Nonsteroidal anti-inflammatory drug.
Advil delivers clinically proven, superior pain relief for a spectrum of pain
Efficacy
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Advil delivers superior relief of osteoarthritis pain vs acetaminophen during 6 hours after the first dose
A clinical study concluded that the active ingredient in Advil (ibuprofen) provided a greater decrease in pain intensity after the initial dose (400 mg) than the active ingredient in Tylenol® (acetaminophen; 1000-mg dose) for acute pain due to OA.
This randomized, parallel-group, double-blind, multicenter study was conducted by Boureau et al to examine the efficacy of single and multiple doses of ibuprofen (1200 mg/day) vs acetaminophen (3000 mg/day) in patients suffering from OA of the knee or hip (N=222).
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Advil delivers superior relief of osteoarthritis pain vs acetaminophen over 14 days
A clinical study concluded that the active ingredient in Advil (ibuprofen) provided a greater decrease in pain intensity over 14 days (400 mg) than the active ingredient in Tylenol® (acetaminophen; 1000-mg dose), each 3 times daily, for acute pain due to OA.
This randomized, parallel-group, double-blind, multicenter study was conducted by Boureau et al to examine the efficacy of single and multiple doses of ibuprofen (1200 mg/day) vs acetaminophen (3000 mg/day) in patients suffering from OA of the knee or hip (N=222).
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Advil offers fast relief of postsurgical dental pain
Pain relief scores in patients taking ibuprofen (400 mg) vs acetaminophen (1000 mg) after the first dose*
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Advil® Liqui-Gels® work fast on dental pain
Advil Liqui-Gels deliver superior relief versus Tylenol® Extra Strength Caplets in patients with postsurgical dental pain.
A single-dose, double-blind, placebo-controlled, randomized clinical trial was conducted to assess relief of acute pain after third molar extraction (N=184).
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Ibuprofen is stronger than acetaminophen + codeine
In a study by Forbes et al on the evaluation of medications on post-operative oral surgery pain, ibuprofen 400 mg was tested against acetaminophen 600 mg as well as acetaminophen 600 mg + codeine 60 mg and was found to be significantly superior in both efficacy and duration.
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Advil delivered superior relief vs Tylenol® in patients with tension-type headaches
In a single-dose, double-blind, randomized, placebo-controlled study by Packman et al (N=154), more patients experienced faster onset to meaningful relief at 30 minutes and complete relief at 3 hours with 400 mg of Advil Liqui-Gels vs 1000 mg of Tylenol® Extra Strength (P<.01).
In another single-dose, double-blind, randomized trial by Schachtel et al (N=455), 400 mg of Advil provided significantly greater analgesic efficacy than 1000 mg of Tylenol® Extra Strength for tension-type headaches.
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Advil delivered more effective pain relief from sore throat than Tylenol®
Advil (400 mg of ibuprofen) was found to be significantly more effective than Tylenol® Extra Strength (1000 mg of acetaminophen) 3 to 6 hours after dosing (P<.01).
A double-blind, single-dose, parallel-group study was conducted to assess the efficacy of Advil vs Tylenol® Extra Strength in patients with sore throat pain (N=120).
Greater meaningful reduction in sore throat pain was achieved by patients treated with Advil at 3 hours and continuing to 6 hours post-dose than by those treated with Tylenol® Extra Strength.
Explore the range of Advil products
Advil Tablets
Advil delivers clinically proven efficacy on the toughest of pains.
Advil Liqui-Gels
The proven power of Advil in a fast-acting liqui gel.
Children’s Advil and Infants’ Advil
Children’s Advil has an excellent safety profile when used as directed.
Infants’ Advil delivers unsurpassed fever relief* that baby can stomach.†
*Based on reducing fever below 100°F.†
†Among leading over-the-counter pain relievers/fever reducers.
Advil Dual Action
A fixed-dose, pain-fighting pair. Advil® Dual Action is a combination of ibuprofen and acetaminophen—two distinct mechanisms of action (MOA) working together to fight pain.
Recommend Advil for clinically proven, effective pain relief with a favorable safety profile
Learn more about Advil and pain relief
Overview of pain conditions
Learn about common pain conditions such as OA pain, headache, sprains & strains and more, and discover how Advil can give your patients relief.
Patient care resources
Access educational resources for your patients, to help them have a better understanding of their pain condition.
