Sensodyne Science: Rapid Relief Powered by Stannous Fluoride

Action of stannous fluoride formulation with inactive polymer

Sensodyne Rapid Relief is specially formulated with stannous fluoride

Engineered for speed: stannous fluoride formulation with polymer (an inactive ingredient) delivers clinically proven relief from dentin hypersensitivity in 3 days with twice daily brushing.¹

Stannous fluoride formulation accelerates occlusion of exposed dentin tubules

The unique formulation with active stannous fluoride and inactive ingredient polymer accelerates occlusion of dentin tubules by:²

Providing additional bio-adhesion within dentin tubules*³
Forming a gel-like scaffold to hold the stannous in place

Study summary

Representative FIB-SEM image of dentine tubules

The Sensodyne Rapid Relief stannous fluoride formulation occludes exposed dentin tubules, helping prevent the movement of fluid^4,5

Representative FIB-SEM image of dentin tubules treated with Sensodyne Rapid Relief, combining multiple imaging techniques (STEM-EDS, DSIMS, FIB-SEM/EDS). The stannous fluoride formulation is shown to extend into the dentin tubules.^4,5

DSIMS, dynamic secondary ion mass spectrometry; FIB-SEM/EDS, focused ion beam scanning electron microscope/energy-dispersive spectroscopy; STEM-EDS, scanning transmission electron microscope energy-dispersive spectroscopy

Clinical summary

Clinically proven sensitivity relief in 3 days with twice daily brushing¹

Stannous fluoride is delivered in an anhydrous (non-aqueous) formulation that is primed to react in the mouth
The non-aqueous formulation ensures stannous fluoride becomes active when in contact with saliva

The stannous fluoride formulation becomes activated in saliva, sticking to dentin and tooth structure and creating a gel-like scaffold that prevents the stannous ions from being washed away
A unique stannous fluoride formulation that has been engineered for speed

Sensodyne Rapid Relief has a unique stannous fluoride formulation with inactive ingredient polymer, and has been shown to reduce fluid flow through dentin tubules by 127% compared with a regular stannous fluoride toothpaste after one application in vitro.*²

Chart adapted from Khan et al>. 2017¹

*vs. toothpaste containing 0.454% stannous fluoride and lower polymer level. Although the active ingredients are the same, the way the toothpastes are formulated affects the way they work. A four-day hydraulic conductance study measuring the fluid flow rates through dentine tubules of two toothpaste formulations. Fluid flow rates were measured after the initial treatment and on Days 1–4. The Pashley hydraulic conductance model and Earles’ solution passed through dentin tubules when a simulation of pulpal pressure was used

Study summary
Dentin tubule occlusion that withstands exposure to dietary acids⁶

SEM* imagery of the dentin surface pre-treatment and post-treatment followed by an acid challenge in vitro.⁶

*SEM, scanning electron microscope

Study summary
Brushing sensitive areas delivers clinically proven relief from sensitivity pain in 3 days with twice daily brushing¹

Sensodyne Rapid Relief with stannous fluoride is clinically proven to relieve sensitivity pain in 3 days with twice daily brushing.¹

Chart adapted from GSK data on file 207211¹

Two additional studies have been conducted: GSK data on file 205710 showing 16% reduction in Schiff score from baseline at 3 days and GSK data on file 205697 showing 33% reduction in Schiff score from baseline at 3 days

*with twice daily brushing

Clinical summary
Sensitivity relief that continues to improve with twice-daily use⁷

A continued reduction in dentin hypersensitivity has been shown after 8 weeks of brushing with Sensodyne Rapid Relief.⁷Long-lasting protection from sensitivity with twice daily brushing.

Chart adapted from Parkinson et al. 2015⁷

^†0.76% w/w sodium monofluorophosphate toothpaste.

Clinical summary