Clinical Summary, Knee OA

Study Objective & Methodology

Three 12-week, randomized, double-blind, parallel-group, placebo-controlled, multicenter trials to compare the safety and efficacy of topical diclofenac sodium gel (DSG) for knee OA in patients aged ≥65 years versus 25–64 years

Results

• In patients aged 25–64 years, application of DSG led to around 47% improvement in pain relief and increased mobility up to 45% from baseline
  
• In patients aged aged ≥65 years, application of DSG led to 44% improvement in pain relief and increased mobility up to 39% from baseline
• DSG provides effective analgesia and potential tolerability benefit with low systemic exposure to adult patients with knee OA pain, regardless of age

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