Caffeine formulations
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Caffeine is an analgesic adjuvant for paracetamol,2-4
The *analgesic adjuvant effects of caffeine are proposed to result from several mechanisms:8,9
- Blockade of the peripheral pronociceptive actions of adenosine
- Activation of central noradrenergic pathways that constitute an endogenous pain suppressing system
- Central nervous system stimulation with a consequent modulation of the affective component of pain
*A minimum concentration of 65mg caffeine in a single dose is required to have a statistically significant adjuvant effect.
Panadol C&F formulations contain 25mg per single dose. Coffee and tea have an estimated caffeine content of 0 – 96mg/237ml and 2-47mg/237ml respectively depending on the variant.
Caffeine enhances the analgesic effect of paracetamol4
Discover the Panadol Cold & Flu Day with caffeine
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Panadol Cold & Flu Day
Panadol Cold & Flu Day contains caffeine. In addition, this product also contains Paracetamol and Phenylephrine.7
Panadol Cold & Flu – Your Cold & Flu Partner
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The Panadol Cold & Flu range
Find out how the PanadolCold & Flurange can help your patients.
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