Otri-allergy Nasal Spray

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Otrivin product

Provides 24-hour relief of allergy symptoms1

  • Nasal congestion
  • Runny nose
  • Sneezing
  • Itchy nose
  • Itchy eyes
  • Watery eyes
6 key inflammatory mediators

Blocks 6 key inflammatory mediators*13-16

Otri-allergy Nasal Allergy works to help block allergic reactions, in order to relieve allergy symptoms through interference with more than 6 key inflammatory substances, including histamine, prostaglandins, cytokines, tryptases, chemokines and leukotrienes.*13-16

*Mechanism vs most allergy pills. Otri-Allergy acts on multiple inflammatory mediators (histamine, prostaglandins, cytokines, tryptases, chemokines, and leukotrienes). The exact number and precise mechanism are unknown.1

Allergy lifestyle image

Very reliable profile with few contraindications9,17,18

Otri-allergy Relief is NOT associated with:

  • Higher blood pressure, and is not contraindicated in patients with hypertension, heart disease, diabetes, liver disease, or kidney disease8,9,17-20
  • Anticholinergic side effects commonly associated with some other allergy medications, such as drowsiness, dry mouth, nervousness, dizziness, or sleeplessness8,9,17-24

Otri-allergy Nasal Spray: Proven 24‐hour Allergy Symptom Relief1

Otrivin product

Otri-allergy Nasal Spray

For patients who are looking for 24-hour relief of nasal and ocular symptoms of allergy.1-12

  • Ingredients

    Active Ingredient: 50 mcg Fluticasone Propionate (glucocorticoid) (0.05% w/w)

    Other ingredients: Dextrose (anhydrous), Microcrystalline cellulose & Sodium carboxymethylcellulose, Phenylethyl alcohol, Benzalkonium chloride, Polysorbate 80, Dilute hydrochloric acid and Purified water.

  • Directions

    Dosing in adults aged 18 years and over:

    • Two sprays into each nostril once a day, preferably in the morning.
    • In some cases, two sprays into each nostril twice daily may be required.
    • The Maximum daily dose should not exceed four sprays into each nostril.
    • Once control is achieved, the dose should be titrated down to one spray in each nostril once a day.
    • The minimum dose at which effective control of symptoms is maintained should be used.
    • Prophylaxis of allergic rhinitis requires treatment before contact with allergen.
    • For full therapeutic benefit regular usage is recommended.
    • Maximum benefit may require 3-4 days of continuous treatment in some people.

    Dose in Elderly:

    • The normal adult dose should be used.

    Children under 18 years of age:

    • Should not be used by children and adolescents under 18 years of age.

    How to use Otri-Allergy:

    1. Shake the bottle well and remove the dust cap.
    2. Blow your nose gently.
    3. Close one nostril and put the nozzle in the other nostril. Tilt your head forward slightly and keep the bottle upright.
    4. Start to breathe in slowly through your nose. While you are breathing in, squirt a spray of fine mist into your nostril by pressing down firmly on the collar with your fingers.
    5. Breathe out through your mouth. Repeat step 4 to take a second spray in the same nostril.
    6. Remove the nozzle from this nostril and breathe out through your mouth.
    7. Repeat steps 3 to 6 for the other nostril.
    8. After using the spray, wipe the nozzle carefully with a clean tissue or handkerchief and replace the dust cap.

  • Warnings & Precautions

    For administration by the intranasal route (nose) only.

    Warning about excipients:

    • This product contains Benzalkonium Chloride which may cause bronchospasm.

    Medical advice should be sought before using this medicine in the case of:

    1. Concomitant use of other corticosteroid products, such as tablets, creams, ointments, asthma medications, similar nasal sprays or eye/nose drops.
    2. Fever or an infection in the nasal passages or sinuses.
    3. Recent injury or surgery to the nose, or problems with ulceration in the nose.
    4. Visual disturbances may occur with systemic and topical corticosteroid use. If a patient presents with symptoms such as blurred vision, they should see an ophthalmologist. Possible causes may be cataract, glaucoma.

    Taking other medicines:

    • Low plasma concentrations of fluticasone propionate are achieved after intranasal dosing, due to extensive first pass metabolism and high systemic clearance mediated by cytochrome P450 3A4. Hence, significant drug interactions are unlikely.
    • Co-treatment with CYP3A inhibitors, including
    • cobicistat-containing products, is expected to increase the risk of systemic side-effects.
    • Other inhibitors of cytochrome P450 3A4 produce negligible (erythromycin) and minor (ketoconazole) increases in systemic exposure to fluticasone propionate without notable reductions in serum cortisol concentrations. Care is advised when co-administering potent inhibitors (e.g. ketoconazole).
    • Ritonavir (a highly potent cytochrome P450 3A4 inhibitor) increased the fluticasone propionate plasma concentrations
    • several hundred-fold, resulting in reduced serum cortisol concentrations. Cases of Cushing’s syndrome and adrenal suppression have been reported. The combination should be avoided unless the benefit outweighs

    Pregnancy and Breast feeding:

    • Medical opinion should be sought, before using this medicine, in the case of pregnancy or breast feeding.
    • As with other drugs, the use of intranasal fluticasone propionate during pregnancy and lactation requires that the benefits be weighed against possible risks associated with the product or with any alternative therapy.

    Driving and using machines:

    • Unlikely to produce an effect.

    Possible side effects:

    • Adverse events are listed below by system organ class and frequency.
    System Organ Class Adverse Event Frequency
    Immune system disorders Hypersensitivity reactions, anaphylaxis/anaphylactic reactions, bronchospasm, skin rash, oedema of the face or tongue Very rare
    Nervosu system disorders Headache, unpleasant taste, unpleasant smell Common
    Eye disorders Glaucoma, raised intraocular pressure, cataract Very rare
    Respiratory thoracic and mediastinal disorders Epistaxis Very common
    Nasal dryness, nasal irritation, throat dryness, throat irritation Common
    Nasal saptal perforation Very rare

    As with other nasal sprays, dryness and irritation of the nose and throat, unpleasant taste and smell, headache and epistaxis have been reported. Nasal ulceration and nasal septal perforation have been reported following the use of intranasal corticosteroids, usually when there has been previous nasal surgery.

    Overdose:

    Administration of doses higher than those recommended over a long period of time may lead to temporary suppression of adrenal function. In these patients, treatment with fluticasone propionate should be continued at a dose sufficient to control symptoms.

Otri-allergy Nasal Spray Product Detail

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