Pronamel Science: Preventing Tooth Erosion and Maintaining Enamel

The unique formulation of Pronamel^1–10

The unique formulation of Pronamel delivers minerals into the enamel to help strengthen and protect^7,11

A unique optimised formulation that delivers superior fluoride uptake*^1,2

Pronamel contains 1450ppm fluoride in an optimised formulation designed to maximise intraoral fluoride. By omitting components that inhibit fluoride uptake, which are present in many fluoride toothpastes, this unique Pronamel dual-action formulation enhances remineralisation and inhibits demineralisation, strengthening and protecting enamel.^1–4

Pronamel optimised formulation:

No phosphates^2,6,7
No polyvalent metal ions⁷
Ionic form of fluoride⁷
No SLS⁸
Neutral pH⁹
Low abrasivity^†10,12

SLS, sodium lauryl sulphate*Compared with tested, non-optimised fluoride toothpastes^†Only Pronamel Daily Protection, Pronamel Extra Freshness and Pronamel For Children

Dual protection for stronger, more resilient enamel^7,13

The unique Pronamel formulation actively improves mineral uptake and leaves enamel more resilient to subsequent acid challenges.^7,13

In vitro SEM images of enamel cross-sections show variations in mineral density¹⁴SEM, scanning electron microscope

Not all fluoride toothpastes are the same^5,15

Sensodyne Pronamel maintains higher levels of fluoride

In an in situ study against a non-optimised fluoride toothpaste, the optimised Pronamel formulation maintained higher levels of fluoride in subjects’ saliva 1 hour after brushing.³

Adapted from GSK data on file RH02217, 2014³
Sensodyne Pronamel creates an environment in the mouth that supports fast remineralisation³

In an in situ study against a non-optimised fluoride toothpaste, the optimised Pronamel formulation1 maintained higher calcium bioavailability in subjects’ saliva.

Adapted from GSK data on file RH02217, 2014³
Sensodyne Pronamel enhances remineralisation by delivering up to 3 times more fluoride uptake into enamel in vitro^†16

Up to 3X higher fluoride uptake^†in vitro vs. a non-optimised, 1450ppm fluoride NaF toothpaste¹⁶

In laboratory studies, Pronamel delivered more fluoride, deeper into the enamel for superior remineralisation vs. a non-optimised fluoride toothpaste.^†16

In vitro cross-sectional DSIMS images of enamel surfacesDSIMS, dynamic secondary ion mass spectrometry^†Based on mean fluoride/oxygen ratio measured at a depth of 20μm; vs. a non-optimised fluoride toothpaste
Sensodyne Pronamel improves mineral uptake, leaving enamel more resilient to subsequent acid challenge⁷

In an in situ study, Pronamel increased the surface microhardness of acid-softened enamel, leaving it stronger and more resilient to dietary acid challenges,^7,17 with 25% greater surface microhardness recovery vs. a non-optimised fluoride toothpaste.⁷

Adapted from Barlow et al. 2009⁷
Sensodyne Pronamel locks in more minerals for superior inhibition of demineralisation^†18

5X greater protection from demineralisation^† in vitro vs. a non-optimised, 1450ppm fluoride NaF toothpaste¹⁸

In laboratory studies, Pronamel inhibited demineralisation of enamel, locking in more minerals vs. a non-optimised fluoride toothpaste.^†18

In vitro cross-sectional BSE-SEM images of enamel surface lesionsBSE-SEM, back-scattered electrons-scanning electron microscope

^†In vitro. Based on mean overall mineral loss; vs. a non-optimised fluoride toothpaste
A gentle formulation helps ensure minimal wear of acid-softened enamel¹⁰

Sensodyne Pronamel has a low abrasion formula, helping to maintain the structural integrity of the enamel surface.*¹⁰

In vitro SEM cross-sectional images of enamel surface structure

*Pronamel Daily Protection and Pronamel Extra Fresh only

Sensodyne Pronamel Intensive Enamel Repair

Sensodyne Pronamel Intensive Enamel Repair is a unique formulation that is proven to drive minerals deep into the enamel surface to help actively repair acid-weakened areas of the enamel, for stronger, better-protected teeth.

Key Ingredient: 0.3152% Sodium Fluoride (1450 ppm fluoride).

Sensodyne Pronamel Toothpaste

Pronamel products are designed to help protect against enamel wear^7,17,19–21

Also available in gentle whitening SKU

Sensodyne Pronamel – helping protect your patients against enamel wear

Enamel wear

Find out more about enamel wear.

Find out more

The Sensodyne Pronamel range

Find out how the Sensodyne Pronamel range can help your patients.

Find out more

Patient care resources

Download resources for your patients.

Find out more

References

Fowler CE et al. J Clin Dent 2009 20:178–185.
Newby CS et al. J Clin Dent 2006; 40:306 (abstr. 10).
GSK data on file RH02217. December, 2014.
GSK data on file 161181. May, 2016.
Layer TM. J Clin Dent 2009; 20:199–202.
Zero DT et al. Caries Res 2000; 34:344 (abstr. 105).
Barlow AP et al. J Clin Dent 2009; 20:192–198.
Barkvoll P et al. Caries Res 1988; 22:139–144.
Friberger P. Scand J Dent Res 1975; 83:339–344.
Creeth JE, Price KS, Wicks MA. J Clin Dent 2006; 17:106–111.
Newby CS et al. J Clin Dent 2006; 17:94–99.
GSK data on file 162366. June, 2016.
Maggio B et al. J Dent 2010; 38:S37–44.
GSK data on file 133333. 2016.
Mason S. J Clin Dent 2009; 20:175–177.
GSK data on file 161077. May, 2016.
Zero DT et al. J Clin Dent 2006; 17:112–116.
GSK data on file 161180. May, 2016.
Fowler C et al. J Clin Dent 2006; 17:100–105.
Fowler C et al. Presentation at the International Association of DentalResearch. Abstract 555. June 2012.
Fowler C et al. Presentation at the International Association of Dental Research. Abstract 3386. March 2011.

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PM-SA-SENO-21-00068Date of Preparation: Dec. 2021

PM-SA-SENO-21-00062Preparation Date: Dec-2023

Pronamel Science: Preventing Tooth Erosion and Maintaining Enamel

The unique formulation of Pronamel1–10

A unique optimised formulation that delivers superior fluoride uptake*1,2

Dual protection for stronger, more resilient enamel7,13

Up to 3X higher fluoride uptake†in vitro vs. a non-optimised, 1450ppm fluoride NaF toothpaste16

5X greater protection from demineralisation† in vitro vs. a non-optimised, 1450ppm fluoride NaF toothpaste18

Sensodyne Pronamel – helping protect your patients against enamel wear

Enamel wear

The Sensodyne Pronamel range

Patient care resources

References

The unique formulation of Pronamel^1–10

A unique optimised formulation that delivers superior fluoride uptake*^1,2

Dual protection for stronger, more resilient enamel^7,13

Up to 3X higher fluoride uptake^†in vitro vs. a non-optimised, 1450ppm fluoride NaF toothpaste¹⁶

5X greater protection from demineralisation^† in vitro vs. a non-optimised, 1450ppm fluoride NaF toothpaste¹⁸