Panadol Ultra

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Panadol Ultra pack shot

For tough pain and inflammation

The combination of proven and trusted pain medicines – ibuprofen and paracetamol.

Combination is conclusively an effective analgesic for stronger pain relief1 and it may also be an effective alternative to oral opioids with comparable efficacy.2

Research also shows that combination treatments may offer better pain relief than diclofenac.3

How does Panadol Ultra relieve pain?

How does Panadol Ultra relieve pain?

Panadol Ultra provides multi-modal analgesia by blocking pain centrally and treating pain at the source of inflammation. It is absorbed within 5 minutes and provides faster pain relief than ibuprofen.

Favorable Efficacy and Safety Profile

Favorable Efficacy and Safety Profile

Panadol Ultra combines 2 of the most widely used analgesics in the world, both with established efficacy and safety profiles.9,10,11

  • Panadol Ultra has a favourable safety profile that is consistent with the known profiles of each active ingredient.12
  • In efficacy and safety trials, no serious adverse events (AEs) were recorded, with all AEs categorized as mild or moderate.12
  • Shown to have fewer adverse events, including nausea, dizziness, and vomiting, and less systemic exposure than ibuprofen or paracetamol alone.
  • No new safety concerns were identified with Panadol Ultra compared to each ingredient alone.

Panadol Ultra is for stronger pain relief across various pain states

  • A middle-aged man suffering from low back pain

    Panadol Ultra in low back pain

    Panadol Ultra reduced low back pain more effectively than a single oral analgesic.4

    Graph showing effectiveness of Panadol Ultra

    A combination of paracetamol and ibuprofen reduced pain better than ibuprofen, improving mobility in low back pain.4

  • Players taking part in sport checking for a musculoskeletal injury

    As per experts, the combination of Paracetamol and Ibuprofen finds itself best positioned for the following musculoskeletal pain states

    • Post-traumatic pain
    • Minor sports traumatology
    • Mild acute pain with inflammatory components (synovitis, bursitis, tendonitis)
    • Stiff neck and painful muscle contractures

    There is a 30% improved efficacy between the two ingredients, higher than monotherapy.5

  • Elderly patient with dentist

    Combination provided greater pain relief compared to monotherapy

    In a study on dental pain, combination of ibuprofen and paracetamol was shown to provide greater relief than either drug alone.2

    Graph showing effectiveness of Panadol Ultra

    APAP, Acetaminophen, or N-acetyl-p aminophenol

    Mean pain relief was recorded on a five-point scale, in which 0 indicated “none,” 1 indicated “a little,” 2 indicated “some,” 3 indicated “a lot” and 4 indicated “complete”*Third molar extraction

  • Woman lying in bed with red heating pad

    Panadol Ultra is effective in treating period pain

    According to a recent meta-analysis, fixed dose combination like Panadol Ultra should be considered as 1st line of treatment option for pain relief.7

    Panadol Ultra targets and treats the cause of pain unlike opioids that mask it.8

Recommend Panadol Ultra

Panadol Ultra packshot

Fights pain two ways for stronger relief

The combination of ibuprofen and paracetamol offers stronger pain relief, provides multi-modal analgesia by blocking pain centrally and treating pain at the source of inflammation.

Panadol Ultra product details

  • Ingredients

    Each film-coated tablet contains ibuprofen 125 mg and paracetamol 250 mg.

    Inactive ingredients carnauba wax, colloidal silicon dioxide, croscarmellose sodium, ferric oxides, glyceryl dibehenate, Hypromellose, pharmaceutical ink, polydextrose, polyethylene glycol, pregelatinized starch, titanium dioxide.

  • Precautions and contraindications

    Do not exceed the recommended dose.6

    Paracetamol:6

    The hazards of paracetamol overdose are greater in patients with non-cirrhotic alcoholic liver disease.

    Immediate medical advice should be sought in the event of an overdose, even if the patient feels well, because of the risk of delayed, serious liver damage.

    Caution is advised if paracetamol is administered concomitantly with flucloxacillin due to increased risk of high anion gap metabolic acidosis (HAGMA), particularly in patients with severe renal impairment, sepsis, malnutrition and other sources of glutathione deficiency (e.g. chronic alcoholism), as well as those using maximum daily doses of paracetamol. Close monitoring, including measurement of urinary 5-oxoproline, is recommended.

    Ibuprofen:6

    Undesirable effects may be minimised by using the lowest effective dose for the shortest duration necessary to control symptoms and by patients taking the dose with food.

    How to recommend Panadol Ultra:

    Adults (including the elderly) and children aged 12 years and over:

    Two tablets (paracetamol 500 mg + ibuprofen 250 mg), every 8 hours as required. Maximum daily dose: 6 tablets per day (paracetamol 1500 mg, Ibuprofen 750 mg). Minimum dosing interval: 8 hours.

  • Side effects

    System Organ Class6 Adverse Events6 Frequency6
    Blood and Lymphatic System Disorders Haematopoietic disorders Very rare
    Immune System Disorders

    Hypersensitivity with urticaria and pruritus

     

    Severe hypersensitivity reactions. Symptomscan include facial, tongue and throat swelling, dyspnoea, tachycardia, hypotension (anaphylaxis, angioedema or severe shock)

    Uncommon

     

    Very rare
    Psychiatric Disorders Confusion, depression and hallucinations Very rare
    Nervous System Disorders

    Headache and dizziness

    Aseptic meningitis, paraesthesia, optic neuritis and somnolence

    Uncommon

    Very rare
    Eye Disorders Visual disturbance Very rare
    Ear and Labyrinth Disorders Tinnitus and vertigo Very rare
    Cardiac Disorders Cardiac failure and oedema4 Very rare
    Vascular Disorders Hypertension4 Very rare
    Respiratory and thoracic and mediastinal disorders Respiratory reactivity including: asthma, exacerbation of asthma, bronchospasm and dyspnoea Very rare
    Gastrointestinal Disorders

    Abdominal pain, vomiting, diarrhoea, nausea, dyspepsia and abdominal discomfort

     

    Peptic ulcer, gastrointestinal perforation or gastrointestinal haemorrhage, melaena, haematemesis, mouth ulceration, exacerbation of colitis and Crohn's disease gastritis, pancreatitis, flatulence and constipation

    Common

     

    Uncommon
    Hepatobiliary Disorders Abnormal liver function, hepatitis and jaundice Very rare
    Skin and Subcutaneous Tissue Disorders

    Hyperhidrosis

     

    Various skin rashes

     

    Bullous reactions including Stevens-Johnson syndrome, erythema multiforme and toxic epidermal necrolysis. Exfoliative dermatoses, purpura

     

    Drug reaction with eosinophilia and systemic symptoms (DRESS syndrome) cute generalised exanthematous pustulosis (AGEP) Photosensitivity reactions

    Common

     

    Uncommon

     

    Very rare

     

     

    Not known
    Renal and Urinary Disorders Nephrotoxicity in various forms, including interstitial nephritis, nephrotic syndrome, and acute and chronic renal failure Very rare
    General Disorders and Administration Site Conditions Fatigue and malaise Very rare
    Investigations

    Alanine aminotransferase increased, gamma-glutamyltransferase increased and liver function tests abnormal with paracetamol. Blood creatinine increased, blood urea increased.

     

    Aspartate aminotransferase increased, blood alkaline phosphatase increased, blood creatine phosphokinease increased, haemoglobin decreased and platelet count increased.

    Common

     

    Uncommon

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