Joint and osteoarthritic pain: Causes

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Understand joint pain and osteoarthritis

Joint pain may be acute or chronic and be associated with a multitude of possible aetiologies.1–3

Here we review some of the potential causes of pain emanating from joint tissues.

Woman holding back

Osteoarthritis is the most common cause of worsening joint pain4,5

The symtoms of joint pain and Osteoarthritis can be similar and its important to notice the difference for correct treatment.

Osteoarthritis is characterised by structural changes within the whole joint – as caused by a multitude of pathogenic factors6–8

  • Mechanical: changes in cartilage composition increase its susceptablility to force-induced erosions.
  • Metabolic: activation of cell-signalling pathways in response to damage leads to further joint degradation.
  • Inflammatory: metabolic activity initiates a proinflammatory response.

This complex process ultimately leads to structural destruction and failure of the synovial joint.8

Man with knee pain

Other conditions may also cause joint pain

Aside from osteoarthritis, a range of conditions can cause joint pain. Acute joint pain, for example, may arise from soft-tissue injuries such as sprains and strains, or overuse injuries or infection.2,3,9 Chronic joint pain however, may be associated with conditions such as tendonitis, bursitis or various forms of arthritis.2–4,10

Soft-tissue injuries are a common cause of acute joint pain. These can include sprains occurring during sports, and overuse injuries.9

Risk factors for osteoarthritis

Woman holding her knee

Certain risk factors for osteoarthritis are known

Although the exact cause of osteoarthritis is unknown, certain factors increase its risk8,11–13:

  • Older age
  • Being female
  • Increased body weight (particularly affects the knees)
  • Family history of osteoarthritis or bone abnormalities
  • Socioeconomic status
  • Injury or overuse of joints (e.g. in athletes)
  • Previous joint trauma (particularly affects the knees)
  • Muscle weakness

Understanding joint pain and osteoarthritis

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Signs and symptoms

Explore an overview of how to recognise joint pain and osteoarthritis and know when to refer patients.

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Management

Learn how joint pain and osteoarthritis can be managed.

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Overview of sprains and strains

Find out about how common sprains and strains are, and meet two patients with these problems.

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Educational resources

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Patient care resources

Access a leaflet for your patients which can help them understand the causes of joint pain and how best to treat it.

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