NovaMin formulations
Sensodyne Repair & Protect Deep Repair is powered by NovaMin
Formulations with NovaMin generate a protective mineral layer over exposed dentine areas to help protect from the pain of sensitive teeth*1,2
*With twice-daily brushing
NovaMin formulations help restore a new hydroxyapatite-like layer over exposed dentine*
NovaMin is specially formulated in Sensodyne Repair & Protect to restore a new tooth-like layer over exposed dentine:*1–7
- Works on contact with saliva to occlude exposed dentine by initiating a cascade of events at the surfaces of teeth
- This results in a rise in pH level in the localised environment, which forms a layer which binds strongly to collagen in exposed dentine
- Once bound to dentine, NovaMin particles promote crystallisation of calcium and phosphate to help create a dynamic protective layer over dentine to help protect against dentine hypersensitivity pain
*Forms a protective layer over the sensitive areas of the teeth. Brush twice a day for lasting sensitivity protection
NovaMin forms a protective layer over exposed dentine for strong repair*1,2
An in vitro cross-section, SEM image of hydroxyapatite-like layer formed by supersaturated NovaMin solution in artificial saliva after five days (no brushing).1
*With twice daily brushingSEM image adapted from Earl et al. 20111SEM, scanning electron microscope
NovaMin forms an occlusive layer over exposed dentine with twice daily brushing1,2
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The hydroxyapatite-like layer bonds to the collagen in exposed dentine1
Transmission Electron Microscopy (TEM) image of dentine at 2000nm
The occluded dentine tubule runs from top to bottom of the image.1
Transmission Electron Microscopy (TEM) image of dentine at 500nm
High magnification showing NovaMin as the occluding material adjacent to inner wall of dentine tubule.1
Transmission Electron Microscopy (TEM) image of dentine at 200nm
Very high magnification of the previous image showing crystalline calcium phosphate deposited adjacent to and among collagen fibres of dentine.1
TEM, transmission electron microscope TEM images are of dentine after 5 days of in vitro NovaMin treatment and are adapted from Earl et al. 20111
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NovaMin works on contact with saliva to occlude exposed dentine1,3,6–11
Scanning electron microscope images of the dentine surface before brushing with NovaMin-formulated toothpaste and the resistant layer formed after1
NovaMin is a Bioglass that uses the natural building blocks of teeth3 to remineralise exposed dentine, forming a crystalline hydroxyapatite layer.1,3,6–11
- Calcium and phosphorous are the two main components of hydroxyapatite, the mineral which teeth are made of – this is key to the mode of action of NovaMin
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NovaMin creates a reparative layer that is structurally similar to dentineǂ1,12
The Ca:P ratio of the hydroxyapatite-like layer is ~1.67, similar to that of dentine and hydroxyapatite1
When overlaid, energy-dispersive X-ray (EDX) microscopy plots of the new reparative layerǂ (hydroxyapatite-like layer) and the dentine surface confirm their similar inorganic compositions.
ǂForms a protective layer over the sensitive areas of the teeth. Brush twice daily for lasting sensitivity protection.
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A clinical study with continued twice-daily use of 5% NovaMin toothpaste demonstrated a reduction in the proportion of teeth with dentine hypersensitivity13,14
53% reduction in the proportion of teeth qualifying as sensitive in response to an evaporative air test (Schiff Sensitivity Scale) after 24 weeks of twice-daily brushing with Sensodyne Repair & Protect with 5% NovaMin.*13,14
Chart adapted from Haleon Data on File RH0189713*Qualifying sensitive teeth met the following inclusion criteria: signs of EAR, GI ≤1, clinical mobility=0, no dentition exclusion and sensitivity to a qualifying air blast. ITT population (n=75)
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A clinical study with continued twice-daily use of 5% NovaMin toothpaste demonstrated improvement in dentine hypersensitivity in response to tactile pressure*13,14
222% improvement in dentine hypersensitivity in response to tactile pressure after 24 weeks of twice-daily brushing with Sensodyne Repair & Protect with 5% NovaMin.*13,14
Chart adapted from Haleon Data on File RH0189713*Maximum tactile pressure was 80g. An increase in tactile threshold indicates an improvement in dentine hypersensitivity. ITT population (n=75)
Sensodyne Repair & Protect Deep Repair
Sensodyne Repair & Protect Deep Repair toothpaste is powered by NovaMin.
No. 1 dentist recommended toothpaste brand for sensitive teeth*
*Dentist Survey, UK, 2023. For verification: mystory.gb@haleon.com
