NovaMin formulations
NovaMin
Sensodyne Clinical Repair toothpastes are formulated with NovaMin, which forms a protective layer over exposed dentine. Clinically proven for long lasting protection against dentine hypersensitivity.*1-3
*With twice-daily brushing
From bioglass to NovaMin3
The first bioglass was invented by American Professor Larry Hench during the Vietnam war, in his pursuit to develop a material that could bond to bone.
NovaMin was first harnessed for oral care applications in 2000’s after use of particulate bioglass materials in clinical applications for bones in the middle ear.
Innovative NovaMin technology
Sensodyne Repair & Protect and Sensodyne Clinical Repair toothpastes are specially formulated with NovaMin. The non-aqueous formulation ensures NovaMin becomes active in saliva, working with natural oral physiology to repair sensitive teeth*2-6
- Once in contact with saliva, NovaMin initiates a cascade of ionic exchanges, involving sodium and hydrogen ions, resulting in a localised pH rise
- The release of sodium ions, coupled with the localised pH rise and the release of calcium and phosphate ions, facilitates the precipitation and crystallisation of a calcium phosphate hydroxycarbonate apatite which binds to collagen fibres in exposed dentine, forming a dynamic protective layer over dentine
- Once bound to dentine, NovaMin particles act as calcium and phosphate reservoirs, forming a protective hydroxyapatite-like layer over exposed dentine tubules to help protect against dentine hypersensitivity pain3**
*forms a protective layer over the sensitive areas of the teeth. Brush twice a day for lasting sensitivity protection**with continued use
NovaMin forms a reparative layer over exposed dentine with twice daily brushing1,2
NovaMin becomes active on contact with saliva
The chemical name for NovaMin is calcium sodium phosphosilicate (CSPS).7 The use of imaging and analysis techniques has demonstrated, in vitro, the reaction of CSPS from an amorphous material to a crystalline hydroxyapatite-like material.7 The calcium and phosphate content of the CSPS are involved in the development of the hydroxyapatite-like material.7 These experiments also confirmed an occlusion mode of action for the management of dentine hypersensitivity.7
NovaMin works on contact with saliva to promote occlusion of exposed dentine.
Image adapted from Earl J et al. 2011. Real time Scanning Transmission Electron Microscopy images of NovaMIn powder in water at a) 0 hours, b) 18 hours, and c) 36 hours.
NovaMin creates a hydroxyapatite-like layer over exposed dentine* 3,4,7,8
The picture above is a scanning electron microscope (SEM) image showing the layer formed on treated dentine samples both over and within dentine tubules.7
The image shows a cross section of the dentine after 5 days treatment. The layer is approximately 1µm thick and has occluded the tubules to at least the depth of the cut.7
The image shows an in vitro SEM cross-section image of the hydroxyapatite-like layer formed by supersaturated NovaMin solution in an artificial saliva after 5 days (with no brushing).7
In vitro studies have shown that the layer formed binds strongly to collagen within exposed dentine.3,4,7,8
*forms a protective layer over the sensitive areas of the teeth. Brush twice a day for lasting sensitivity protection. SEM image adapted from Earl et al. 20117
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The hydroxyapatite-like layer bonds to the collagen in exposed dentine1
Transmission Electron Microscopy (TEM) image of dentine at 2000nm
The occluded dentine tubule runs from top to bottom of the image.1
Transmission Electron Microscopy (TEM) image of dentine at 500nm
High magnification showing NovaMin as the occluding material adjacent to inner wall of dentine tubule.1
Transmission Electron Microscopy (TEM) image of dentine at 200nm
Very high magnification of the previous image showing crystalline calcium phosphate deposited adjacent to and among collagen fibres of dentine.1
TEM images are of dentine after 5 days of in vitro NovaMin treatment and are adapted from Earl et al. 20111
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NovaMin forms a reparative hydroxyapatite-like layer over exposed dentine which is resistant to everyday oral challenges1,6,8,9
NovaMin toothpastes form a reparative hydroxyapatite-like layer over exposed dentine which is resistant to everyday oral challenges
In vitro studies have demonstrated the robustness of the layer to chemical (dietary acid) challenge (Earl et al, 2011; Burwell et. al., 2010; Wang et. al., 2010; Parkinson et al 2011).1,6,8,9
In vitro studies have demonstrated the robustness of the layer to physical challenge (brushing and microhardness indenter) (Parkinson et al 2011).8
The SEM images, from an in vitro study conducted in 2011, show the dentine surface pre-treatment, post-brushing and post-acid challenge, respectively.1
Image adapted from Earl et al 2011.1 Brushing challenge: 200 brush strokes with wet (deionized water) medium bristle manual tooth brushing machine. In vitro SEM images of the tooth surface after twice-daily brushing for 4 days with water, of a reparative layer formed after twice-daily brushing for 4 days with a Novamin technology, and of the reparative layer post 5-minute cola challenge. Control = Dentine surface after 4 days brushing with water and immersion in artificial saliva.
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NovaMin forms a reparative layer over exposed dentine* that is harder than natural dentine
The Ca:P ratio of the hydroxyapatite-like layer is ~1.67, similar to that of dentine and hydroxyapatite1
When overlaid, energy-dispersive X-ray microscopy plots of the new reparative layer (hydroxyapatite-like layer) and the dentine surface confirm their similar inorganic compositions.7
*forms a protective layer over the sensitive areas of the teeth. Brush twice a day for lasting sensitivity protection.
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NovaMin forms a reparative layer, harder than dentine*6-10
An in vitro study conducted in 2024 showed the hydroxyapatite-like layer formed with NovaMin is 76% harder than the dentine control.
Following 4 days of twice-daily brushing, dentine samples were assessed for surface microhardness using a Berkovich indenter tip.
After 4 days of treatment the NovaMin toothpaste formulation produced a significantly harder layer (P<0.05), compared to other occluding technologies, with a hardness value of 0.044 +0.09GPa. The layer was also significantly harder than the dentine control (P<0.05).
The graph shows the layer hardness after brushing and includes a representation for the hardness of dentine following treatment with artificial saliva (control) which shows the layer formed by NovaMin is harder than dentine.
*from in vitro/laboratory studies measuring layer hardness using an indentation method after 4 days, twice daily brushing. Graph adapted from Haleon Data on File, Report QD-RPT-118201; 2024;10 accepted for presentation at IADR New Orleans 2024. Colgate contains Arginine.
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NovaMin: more comprehensive occlusion than many other occluding toothpastes in vitro11
This in vitro study was conducted using a Hydraulic Conductance model to determine the reduction in fluid flow rate through dentine tubules, which correlates to tubule occlusion. Samples were sourced for this study in 2022 and the study was presented at IADR 2023.11
Three toothpastes were shown to be significantly more effective in occluding dentine tubules than the rest of the toothpastes, with Sensodyne non-aqueous toothpaste containing NovaMin reducing the flow rate significantly (96.05%; p≤0.03) more than other tested products.
Chart adapted from Moghaddam B, et al. Benchmarking Hydraulic Conductance Study on Market Leading Sensitivity Toothpastes. Presentation at IADR 202311
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Clinically proven to relieve sensitivity in 14 days*12
Clinically significant sensitivity improvements in 14 days*12
This exploratory, randomised, examiner blind, parallel group, 11-week controlled study was completed in healthy adults with self-reported and clinically diagnosed dentine hypersensitivity with 135 subjects randomised to treatment.
The 3 treatment groups used either a) toothpaste with 5% NovaMin + fluoride, b) toothpaste with arginine, calcium carbonate + fluoride or c) a regular toothpaste.
Two independent stimulus-based efficacy measures were used to assess DH: tactile (using a Yeaple probe) and evaporative (air) sensitivity (Schiff sensitivity score).
The 5% NovaMin toothpaste was shown to be effective in relieving dentine hypersensitivity in 2 weeks and improvements continued throughout the 12-week study.
*with continued use
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Clinically proven to provide long-lasting sensitivity relief*13,14
Effective protection against the pain of sensitive teeth, and resilient repair*
This data is from a 24 week, non-comparative clinical study in healthy adults (n=75) with clinically confirmed dentine hypersensitivity (DH). Subjects brushed for 24 weeks with a non-aqueous toothpaste with 5% NovaMin and 1426ppm fluoride.
DH was assessed at intervals over the 24-week period in response to evaporative (air) stimulus (Schiff sensitivity score) and a tactile stimulus.
All sensitivity measures demonstrated clinically significant ongoing reductions compared with baseline over the 24-week period.
This long-term data demonstrates ongoing protection over 6 months with twice daily brushing, associated with improved oral health-related quality of life.13,14
*with continued use Graph adapted from Haleon Data on File study RH01897 synopsis report 2014.14
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Clinically proven improvements in oral health-related quality of life*13,14
This is from the same 24 week study described above. The dentine hypersensitivity experience questionnaire (DHEQ) was used to assess changes in subject-perceived DH before and during treatment in addition to traditional DH pain scores. These measures are indicative of oral health related quality of life (OHrQoL).
All DHEQ measures, with the exception of the global oral health rating, demonstrated ongoing improvements in OHRQoL across the extended study period.13,14
*with twice daily brushing Chart adapted from Haleon Data on File Study RH01897 Synopsis Report 2014.14
Sensodyne Clinical Repair toothpastes with NovaMin
The Sensodyne Clinical Repair toothpaste range is our next generation Sensodyne with 5% NovaMin.
Sensodyne Repair & Protect toothpaste
Sensodyne Repair & Protect toothpastes are powered by NovaMin.
No. 1 dentist recommended toothpaste brand for sensitive teeth*
*Dentist Survey, UK, 2023. For verification: mystory.gb@haleon.com
