Phenylephrine formulations
Several Panadol products are specially formulated with phenylephrine hydrochloride
In addition to the other ingredients for the relief of colds and flu, formulations with phenylephrine provide clinically proven relief from nasal congestion.1,2
Phenylephrine is an alpha-1 adrenergic agonist
Phenylephrine is an alpha-1 adrenergic agonist with multiple actions when administered topically or systemically. In addition, phenylephrine opens up the nose by constricting the large nasal veins in the anterior part of the nose that control nasal airway resistance.3,10
Phenylephrine causes vasoconstriction of the nasal mucosa vasculature to improve nasal congestion1,2
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Phenylephrine Hydrochloride is a sympathomimetic agent commonly used for the symptomatic relief of nasal congestion5-8
![Graph comparing improvement to airflow resistance between phenylephrine and placebo]()
Graph comparing improvement to airflow resistance between phenylephrine and placebo
Phenylephrine provided significant improvement to nasal airflow after 30 minutes.9
![Graph comparing phenylephrine vs placebo decongesting nasal passages]()
Graph shows how effective phenylephrine 10mg is at decongesting the nasal passages
In a meta-analysis of seven crossover studies and a reanalysis of a parallel-group study in 113 patients with acute nasal congestion due to the common cold.2
Phenylephrine 10 mg (1 x capsule) was significantly more effective (p <0.05) than placebo in reducing nasal airway resistance at 30 minutes after dosing.2
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Phenylephrine hydrochloride has nasal decongestant activity and reduces oedema1
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Compared to topical administration, oral intake of phenylephrine reduces the risk of rebound congestion
When delivered systemically, decongestants such as phenylephrine may have a slower onset of action and a less dramatic constriction of small nasal blood vessels compared with when used topically, so they are less likely to cause rebound nasal congestion.4
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Phenylephrine for cold and flu relief
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Phenylephrine is used to relieve cold and flu symptoms
Phenylephrine may be used in combination with other active ingredients such as paracetamol to relieve the symptoms of the common cold or flu.1,4
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Side Effects
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The following adverse reactions have been observed in clinical trials with phenylephrine and may therefore represent the common adverse reactions with phenylephrine; Nervousness, headache, dizziness, insomnia, nausea and vomiting have been noted with the use of phenylephrine, as have acute angle closure glaucoma, immune system disorders such as allergic dermatitis, and dysuria or urinary retention.1
Discover the Panadol range with phenylephrine
Panadol Cold & Flu Day
Panadol Cold & Flu Day decongests the nose with phenylephrine. In addition, this product also contains Paracetamol and Caffeine for the relief of various cold and flu symptoms.11
Panadol Cold & Flu – Your Cold & Flu Partner
