Overview
Advil contains ibuprofen — a nonsteroidal anti-inflammatory drug (NSAID)
Ibuprofen is the active ingredient in Advil and Children’s Advil that relieves pain and reduces fever. Like all NSAIDs, ibuprofen is an analgesic, antipyretic, and anti-inflammatory.1,2
OTC ibuprofen has a well-established clinical safety profile that is demonstrated across multiple clinical studies.1OTC = over the counter.
The principal mechanism of action (MOA) of ibuprofen and other NSAIDs is inhibition of prostaglandin biosynthesis1
One of the principle actions of NSAIDs in delivering effective analgesic and anti-inflammatory activity is via decrease of prostaglandin biosynthesis by inhibiting cyclooxygenase.1
MOA Key Points:
- Prostaglandins are naturally-occurring fatty acid derivatives that are believed to be a common factor in the production of pain, fever and inflammation.1
- Prostaglandins are widely distributed and believed to sensitize tissues to pain and inflammation through mediators such as histamine, 5-hydroxytryptamine, and kinins. 1
- Cyclooxygenases (i.e., COX1 and COX2) are the enzymes that catalyze the committed step in prostaglandin biosynthesis that NSAIDs such as ibuprofen inhibit to prevent prostaglandin production.1,3
NSAID = nonsteroidal anti-inflammatory drug.
Demonstrated efficacy and a well-established safety profile1,2,5*
One Advil is often all it takes to relieve mild to moderate acute pain including:1
- Sore throat pain
- Headache & migraine
- Muscle aches
- Menstrual pain
- Toothache (dental pain)
Advil also reduces fever.
There is considerable evidence documenting the efficacy of both the 200 mg and 400 mg doses of ibuprofen in the treatment of mild to moderate acute pain in a range of pain models.1
Low dose (<1200 mg/day) and short duration use of ibuprofen has a well-demonstrated clinical tolerability profile comparable to acetaminophen.1,6-9
* Advil should not be taken for fever for more than 3 days or for pain for more than 5 days unless directed by a physician. Please consult the Product Monograph for complete dosing and safety profile.1Please consult the Product Monograph available upon request (1-855-367-7349) or on the Health Canada website₹ for information to assist in benefit-risk assessment. Always direct the patient to read the label.
Children’s Advil manages acute pain and fever with a range of well studied and effective products.
Ibuprofen containing products
Children’s Advil Pediatric Drops Ibuprofen Oral Suspension, 40 mg/mL
Relieves fever for up to 8 hours. Includes an oral syringe for precise dosing. For ages 4 months to 3 years.2
Children’s Advil Ibuprofen Oral Suspension, 100 mg/5 mL
Reduces fever and relieves pain, providing up to 8 hours of relief.2
Children’s Advil Cold and Flu Multi-symptom, 100 mg/5 mL
Relieves combined symptoms associated with cold and flu: stuffy nose, fever, body aches, sore throat, headache, runny nose, sneezing, itchy, watery eyes, and sinus pain.10
Children’s Advil Chewable Ibuprofen Tablets, 100 mg
Relieves fever and pain due to colds or flu, sore throat, immunization, and earache. Ages 2–12 years.2
Advil Liqui-Gels Ibuprofen Capsules, 200 mg
Relieves migraines, headaches, fever, muscle & joint pain.1
Advil 12 Hour Ibuprofen Extended Release Tablets BP, 600 mg
Designed with dual-layer technology for up to 12 hours of pain relief with one pill.1
Advil Arthritis Pain Ibuprofen Capsules, 400 mg
Goes to work at the site of inflammation pain, providing liquid fast relief.1
Advil Muscle & Joint Ibuprofen Tablets USP, 400 mg
For fast and effective relief of muscle & joint pain, body pain, and sprains and strains.1
Advil — for all your patients’ acute pain relief needs
Advil products
Help your patients manage their acute pain and fever with our full range of well studied and effective pain-relieving products.1,2,5
