Advil Plus Acetaminophen
Fights pain in 2 ways to deliver up to 8 hours of pain relief
Advil Plus Acetaminophen is a fixed-dose combination of ibuprofen and acetaminophen—two distinct mechanisms of action (MoA) that fight pain in two ways.1
But how do they work?
Ibuprofen
Ibuprofen, a “traditional” NSAID, decreases the synthesis of pain- and inflammation-promoting prostaglandins via nonselective inhibition of COX-1 and COX-2.1,2
NSAID = Nonsteroidal anti-inflammatory drug.COX = cyclooxygenase.
Acetaminophen
Acetaminophen, a non-NSAID analgesic, has a mechanism of action that is not yet clear. However, it may exert its effects via CNS COX inhibition and activation of central serotonergic pathways.1-3
CNS: central nervous system; COX = cyclooxygenase; NSAID = nonsteroidal anti-inflammatory drug.
The best of both worlds
The active ingredients in Advil Plus Acetaminophen work well together to fight pain in two ways for effective relief while requiring lower maximum daily doses of each medicine.1,4*
For more information on how well this works, please review our efficacy below.
* With Advil Plus Acetaminophen, the maximum daily dose is 750 mg ibuprofen and 1500 mg acetaminophen vs. 1200 mg and 4000 mg, which are the maximum daily doses for over-the-counter (OTC) ibuprofen and acetaminophen alone (respectively).5,6
Advil Plus Acetaminophen is more than each of its parts
In a single dose dental pain study, Advil Plus Acetaminophen provided significantly greater analgesic efficacy across the primary endpoint* and a majority of secondary endpoints† than either ibuprofen 250 mg or acetaminophen 650 mg alone.1,4
* Time weighted sum of pain intensity differences over 8 and 24 hours.4† Refer to Searle S et al., 2020 for a complete list of secondary endpoints in Study 1 and Study 2.
Fast, Long, and Effective Pain Relief
Advil Plus Acetaminophen demonstrated a fast onset of action, with longer duration of relief of up to 8 hours compared to acetaminophen 650 mg and provided greater analgesic efficacy than either ibuprofen 250 mg or acetaminophen 650 mg alone.1,4
Names you know and trust
Advil Plus Acetaminophen combines two of the most widely used analgesics in the world, both with established efficacy and safety profiles.2,3,7
Advil Plus Acetaminophen has a favorable safety profile that is consistent with the known profiles of each active ingredient.4*
Safety and efficacy were evaluated in 7 clinical studies, including pharmacokinetic studies, and 4 efficacy studies in pain and fever relief. There were no serious adverse events or deaths reported in these studies, and treatment related adverse events were mild or moderate in severity. The overall exposure in the clinical program included 1477 subjects.1,4
No new safety concerns were identified in the clinical program with Advil Plus Acetaminophen compared to each ingredient alone.1,4
For specific warnings associated with acetaminophen and NSAID use, please refer to the Product Monograph.
* As supported by published clinical data. Advil Plus Acetaminophen contains acetaminophen. Patients should not take more than 6 tablets within 24 hours (maximum daily amount), other drugs that contain acetaminophen, and should not take it while drinking 3 or more alcoholic drinks every day. Patients who have or have previously had heart failure, high blood pressure, liver or kidney disease, or who are pregnant, or nursing should talk to their doctor before taking acetaminophen.
-
Less ibuprofen
Lower maximum daily dose of ibuprofen, effective pain relief
With Advil Plus Acetaminophen, the maximum over-the-counter daily dose of ibuprofen is 750 mg vs. 1200 mg, which is the maximum over-the-counter daily dose for ibuprofen alone. When patients take Advil Plus Acetaminophen, they are taking 37.5% less ibuprofen vs. the daily maximum dose.1,4*
* With Advil Plus Acetaminophen, the maximum daily dose is 750 mg ibuprofen and 1500 mg acetaminophen vs. 1200 mg and 4000 mg, which are the maximum daily doses for over-the-counter (OTC) ibuprofen and acetaminophen alone (respectively).5,6
-
Less acetaminophen
Lower maximum daily dose of acetaminophen, effective pain relief
With Advil Plus Acetaminophen, the maximum over-the-counter daily dose of acetaminophen is 1500 mg vs. 4000 mg, which is the maximum over-the-counter daily dose for acetaminophen alone. When patients take Advil Plus Acetaminophen, they are taking 62.5% less acetaminophen vs. the daily maximum dose.1,4*
* With Advil Plus Acetaminophen, the maximum daily dose is 750 mg ibuprofen and 1500 mg acetaminophen vs. 1200 mg and 4000 mg, which are the maximum daily doses for over-the-counter (OTC) ibuprofen and acetaminophen alone (respectively).5,6
Gabriella wants fast, effective relief for her tension headache pain
Gabriella* is a busy, working lawyer. When a tension headache starts to slow her down and keeps her away from her work, she needs relief fast.
Her pain: tension headache.
Advil Plus Acetaminophen acts fast and effectively fights pain in two ways to relieve the pain from tension headaches, with lower maximum daily doses of each medicine.1†
* Fictional case study.† With Advil Plus Acetaminophen, the maximum daily dose is 750 mg ibuprofen and 1500 mg acetaminophen vs. 1200 mg and 4000 mg, which are the maximum daily doses for over-the-counter (OTC) ibuprofen and acetaminophen alone (respectively).5,6
Recommend Advil Plus Acetaminophen for pain relief with lower maximum daily doses of each medicine
Advil Plus Acetaminophen
An effective combination of ibuprofen and acetaminophen that fights pain in 2 ways.1
Advil Plus Acetaminophen relieves:1
migraine pain, tension headache, dental pain, premenstrual/menstrual pain, muscle sprains & strains, joint & body pain, and pain from inflammation including arthritis. Advil Plus Acetaminophen reduces fever.
Learn more about Advil Plus Acetaminophen
Advil Plus Acetaminophen Patient Leaflet
This leaflet is Part III of the approved Product Monograph for Advil Plus Acetaminophen and is a summary of helpful information for patients.
Patient samples for Pharmacists & Doctors
Provide your patients with OTC product samples when you make your expert recommendation.
About tension headache
Learn more about tension headaches and how Advil Plus Acetaminophen may be able to help.
